Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study
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چکیده
منابع مشابه
Exploring the Causal Pathway From Telomere Length to Coronary Heart Disease: A Network Mendelian Randomization Study.
RATIONALE Observational studies have found shorter leukocyte telomere length (TL) to be a risk factor for coronary heart disease (CHD), and recently the association was suggested to be causal. However, the relationship between TL and common metabolic risk factors for CHD is not well understood. Whether these risk factors could explain pathways from TL to CHD warrants further attention. OBJECT...
متن کاملAssociation Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Importance The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of t...
متن کاملMendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملNetwork Mendelian Randomization Study Design to Assess Factors Mediating the Causal Link Between Telomere Length and Heart Disease.
Mendelian randomization study designs represent new powerful tools available to researchers that enable causal inferences to be made about the effects of risk factors in health and disease outcomes in the context of a prospective observational study. These study designs involve estimating the association between a genetically modifiable risk factor and health and disease outcomes. If individual...
متن کاملGenetic determinants of telomere length and risk of common cancers: a Mendelian randomization study
Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. These inconsistencies are likely attributable, in part, to biases that arise due to post-diagnostic and post-treatment TL measurement. To avoid such biases, we used a Mendelian randomization approach and estimated associations between nine TL-associated SNPs and risk for fi...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2021
ISSN: 1734-1922,1896-9151
DOI: 10.5114/aoms/119965